An article titled „Reference intervals for six salivary cortisol measures based on the Croatian Late Adolescence Stress Study (CLASS)“ by Daniela Šupe-Domić, Goran Milas, Lada Stanišić, Irena Drmić Hofman i Irena Martinović Klarić was published in the prominent journal for biochemical research Biochemia Medica, 28 (1).

The levels of salivary cortisol have been widely recognized in stress studies as a reliable biomarker that indicates the respondents’ exposure to stress. The aim of this nested study is to provide the reference intervals for already published measurements of salivary cortisol from the Croatian Adolescence Stress Study (CLASS). The research was conducted on a sample of 969 subjects (372 girls and 597 young men aged 18 to 21) whose saliva samples were taken at three time points during one day. The obtained reference values of salivary cortisol measurements open the arena for introducing salivary bioscience in Croatian clinical laboratory practice and provide important data for better understanding of gender differences in adaptation to stress during late adolescence.

The article is available at the ISRZ Repository: